Bydureon (exenatide) is an injectable prescription drug that can improve blood sugar (glucose) levels in adults with type 2 diabetes, and should be used along with diet and exercise. Can bydureon be used with insulin?
Interactions between your medications
Co-administration of exenatide with insulin may increase the risk of hypoglycaemia or lowering of blood sugar levels. You may need to adjust your dose or monitor your blood sugar level more often to use both medicines safely. Tell your doctor if hypoglycaemia occurs during treatment. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, sweating, palpitations and rapid heartbeat. It is important to tell your doctor about all other medicines you use, including vitamins and herbs. Do not stop using any medications without talking to your doctor first.
Research on Bydureonem
Extended approval was supported by data from the DURATION-7 study, which compared Bydureon with placebo as an adjunctive therapy with insulin glargine, with or without metformin, in adults with type 2 diabetes. Patients with a mean baseline HbA1c of 8.5% who received Bydureon, there was a mean decrease in HbA1c of 0.9% compared to 0.2% in the placebo arm (difference 0.6%; P <0.001).
In addition, more patients in the Bydureon group achieved HbA1c <7.0% compared to patients in the placebo group (32.5% vs. 7.0%). No new safety signals were observed in the study; the percentage of overall hypoglycemia was similar in both treatment groups (29.7% vs. 29.0%). The most commonly reported adverse events were nausea, diarrhea, headache, vomiting, constipation, injection site pruritus, injection site lump and indigestion.
How does Bydureon work?
After starting BYDUREON, each weekly dose ensures a gradual increase in the amount of exenatide in the blood when it is released from the microspheres (fine particles)
It takes 6-7 weeks for exenatide in the blood to reach optimal levels for work in the body or the so-called steady state. Thereafter, exenatide levels are maintained with continuing injections once a week
Sometimes patients may get a small tumor (lump) under the skin associated with the microspheres. When this happens, it usually disappears within 4 weeks on average
- Serious injection site reactions, with or without tumors, have occurred in some people using BYDUREON. Read more in the Important Safety Information below
- Some side effects may occur. Some of the most common side effects with BYDUREON include nausea, diarrhea, headache, vomiting, constipation, itching at the injection site, small injection site bump (bump) and indigestion
- These are not all BYDUREON side effects. Talk to your doctor or other healthcare professional about any side effects that worry you or don’t go away
What medicines can Bydureon be used for?
Bydureon can be prescribed as a triple treatment regimen in combination with the following:
- Metformin and a sulphonylurea
- Metformin and thiazolidinedione
Alternatively, Bydureon can be prescribed as a double therapy with metformin or a sulphonylurea.